A CLINICAL CASE OF CHRONIC HYPOCALCEMIA AND FAHR SYNDROME WITH SEVEREMULTI-ORGAN DAMAGE

Abstract

Clinically significant hypocalcemia is a common cause of emergency conditions in medical practice requiring hospitalization. Pseudohypoparathyroidism (PHP) is an unusual and rare etiologic nox of hypocalcemia. PHP refers to a group of diseases, characterized by resistance of target tissues to parathyroid hormone (PTH). A clinical case of a 42-year-old woman is presented, who was treated twice in Hospital “Heart and Brain” – Pleven with symptoms of mental retardation, rhythm and conduction disorders -atrial fibrillation, dilated cardiomyopathy, congestive heart failure, multiple seizures with loss of consciousness and tetanic-clonic seizures. The clinical and laboratory characteristics include short stature, short neck, centripetal obesity, short IV metatarsal bones, mental retardation, soft tissue and intracranial calcifications (newly diagnosed Fahr’s syndrome), subclinical hypothyroidism, late and incomplete puberty, severe hypocalcemia, and high levels of PTH overlapping with the clinical characteristics of PHP type Ia. Soft tissue calcium deposits in diseases associated with chronic hypocalcemia cause multi-organ damage, disability, and poor prognosis among these patients.